The overarching goal of our research is to understand how two intimately related cellular organelles,  the centrosome and cilium, organize signaling pathways that influence important cellular functions. These highly conserved organelles are involved in regulation of cell-cycle progression,  cell differentiation, polarity, and migration. Defects in the structure and function of 

 

Research Overview:

Mahjoub

Lab

The Mahjoub Lab
Centrosome schematic

The centrosome and cilium

centrosomes and cilia lead to a range of human disease phenotypes known collectively as “Ciliopathies”. These include developmental defects such as polycystic kidney disease, polydactyly,  infertility, hydrocephalus and cancer, as well as neurocognitive defects including mental retardation and dyslexia.

We employ genomic, proteomic, biochemical and cell biological methods to delineate the regulation of centrosome-cilium assembly and function. We are interested in determining the consequences of abnormal centrosome and cilium function in human disease, with particular emphasis on the development of ciliopathies affecting the kidney, such as polycystic kidney disease, nephronophthisis and cancer.

We are looking for talented and enthusiastic undergraduates, graduate students and postdoctoral fellows to join our team. Please email Dr. Mahjoub with a letter of interest and curriculum vitae.